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Are CB2 receptors a potential therapeutic target for neuroinflammatory diseases in humans?

Year:
2010
Duration:
60 months
Approved budget:
$500,000.00
Researchers:
Dr Scott Graham
Health issue:
CNS/neurological
Proposal type:
Sir Charles Hercus Fellowship
Lay summary
Inflammation is the hallmark of most neurological diseases. CB2 drugs have demonstrated considerable promise in several neurological rodent models of disease but remain relatively untested in humans. The project will investigate the regulation of the pro-inflammatory activity of human immune-cells by CB2 and assess their potential as therapeutic-targets for neuroinflammation.