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Management of neonatal hyperglycaemia

1 month
Approved budget:
Dr Kathryn Williamson
Health issue:
Obstetric complications/perinatal care
Proposal type:
Clinical Research Training Fellowship
Lay summary
High blood glucose concentrations (hyperglycaemia) are common in preterm babies and are associated with high rates of morbidity and mortality. Neonatal hyperglycaemia is commonly treated with insulin, although there is little evidence to show that this is beneficial. Indeed, in preterm babies, insulin can cause low blood glucose concentrations, and this can itself cause brain damage. Thus, the complications from current treatment of neonatal hyperglycaemia could be causing more harm than the hyperglycaemia itself. Our planned randomised controlled trial of insulin treatment in hyperglycaemic preterm babies will demonstrate if computer-determined dosing will allow safer administration of insulin, thereby providing evidence to inform practice. Following successful completion of training as a neonatologist, I am now focused on developing a career in research. This study will allow me to complete a PhD and acquire skills necessary to become an academic neonatologist.