Lay summary
With an aging population, cataracts are becoming increasingly common, driving up demand for cataract surgery and placing significant pressure on hospital systems, leading to long waiting times. Oxidative damage is well established as a key contributor to cataract formation, yet antioxidant-based therapies have so far proven ineffective in slowing cataract onset, largely due to inadequate delivery to the lens. We propose that the lens microcirculation system can be harnessed to enhance water transport and, in turn, improve antioxidant delivery to the lens. This study will identify and test compounds that upregulate the microcirculation system, used in combination with protective cysteine-based antioxidants, to strengthen the lens defences against oxidative stress and delay cataract development. The potential research impact is substantial: transforming cataract management, reducing reliance on surgery, lowering healthcare costs, and improving health outcomes for our aging population.