Lay summary
Novel psychoactive substances containing synthetic cannabinoids are the most rapidly growing class of recreational drugs. Synthetic cannabinoid products have effects similar to those of natural cannabis, yet, these drugs are more potent and dangerous, and have been associated with serious adverse effects, including over 20 deaths in New Zealand in the past year. In this application we aim to understand the diverse molecular signalling of these compounds, and correlate these with the adverse effects. This knowledge would inform policy around these compounds, and treatment strategies as well as broadening our understanding of the endocannabinoid system.