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Corneal nerve microstructural changes in diabetes

45 months
Approved budget:
Dr Stuti Misra
Health issue:
Proposal type:
Emerging Researcher First Grant
Lay summary
Bariatric or gastric bypass surgery is an effective treatment option for patients with morbid obesity-associated diabetes. This type of surgery is expected to double within the next few years. Bypass surgery leads to an immediate improvement in diabetes and related complications. The overall theme of the current project is monitoring changes (reversal or progression) of diabetic peripheral neuropathy using imaging of front part of the eye (cornea). In vivo confocal microscopy of cornea is a unique painless method enabling direct observation of nerves in the living human eye. The first part of the study aims to determine changes in the eye after bypass surgery which may provide an objective measure to assess reduction of peripheral neuropathy. The second part of the study involves re-reviewing diabetic patients (fully evaluated 5 years ago) to determine corneal changes and their association with diabetic peripheral neuropathy, and overall longitudinal relationship with diabetes control.