Equity of Māori health outcomes is essential for the wider social and economic advancement of Aotearoa. This collaborative programme of research, hosted by an iwi-owned research centre, comprises an integrated suite of Māori-led studies that seek to contribute to the achievement of equitable health outcomes. The programme will explore the positive change that can occur when Māori have the opportunity to drive solutions and work in authentic partnership models. Underpinned by kaupapa Māori methodology, tikanga Māori, Māori worldviews and Māori ways of operating are pivotal aspects of the research design. The collaborative, cross-disciplinary team brought together in this programme has a wealth of experience in working alongside Māori communities to frame and implement research that seeks to contribute to enhanced wellbeing outcomes. Co-creation of solutions with whānau, and a focus on translation, uptake and impacts of research results, are novel elements of the programme.