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Lost in translation: translation dysregulation and Parkinson's disease

41 months
Approved budget:
Dr Ivanhoe Leung
Health issue:
Neurological (CNS)
Proposal type:
Emerging Researcher First Grant
Lay summary
The objective of our project is to understand the causes of Parkinson’s disease from molecular, biochemical and structural perspectives. We aim to achieve our goal by studying how a mutant enzyme called LRRK2, which can be found in up to ~40% of Parkinson’s cases in some ethnic groups, changes the structure, dynamics and function of its substrate, which is a ribosomal protein called s15 that is involved in the assembly of ribosome in translation and protein synthesis.