Poverty, infectious diseases, and serious long-term conditions such as stomach cancer and diabetes tend to occur together (termed ‘syndemics’). The SYMBIOTIC Programme team will work in partnership with communities, practitioners, Māori health providers, and policymakers to create practical, effective solutions to break syndemic cycles and advance health and equity. The Programme will both use and further develop New Zealand's rich data environment to inform action against syndemics, with a focus on better vaccination policy; improved safety of the food supply and drinking water; reducing unnecessary use of antibiotics; screening and treatment for H. pylori stomach infection; and improved understanding and management of patients with multiple long-term conditions. Whānau-centred care offers the integrated approach that is essential to address syndemics. A key strength of the Programme is the community co-design model that will guide development of the research evidence and its implementation in policy and practice.