Human cells in our body communicate with one another through multiple pathways. One established route is via their ability to produce a range of different signalling “packages”, called vesicles. These packages can travel between our cells and around our body delivering a range of chemical messages. Here we propose a new function for these vesicles that provides a novel communication activity and axis. This axis is likely to underpin a new fundamental biological interaction that will have major relevance to normal as well as disease states in our bodies.