Infectious diseases account for 15-20% of global mortality, with the highest incidence in resource-poor settings. Vaccination against infectious disease remains the most effective medical intervention. We will use a novel molecular ‘superglue’ we have developed to engineer vaccines that are effective against highly diversified pathogens. These multi-component vaccines spontaneously assemble themselves during manufacture. This promises to make production of vaccines much simpler, accelerating the development of more efficient vaccines.